Promiscuous, Multi-Target Lupane-Type Triterpenoids Inhibits Wild Type and Drug Resistant HIV-1 Replication Through the Interference With Several Targets

• Main Authors: Luis M. Bedoya (Author), Manuela Beltrán (Author), Javier García-Pérez (Author), Patricia Obregón-Calderón (Author), Oliver Callies (Author), Ignacio A. Jímenez (Author), Isabel L. Bazzocchi (Author), José Alcamí (Author)
• 格式: 图书
• 出版: Frontiers Media S.A., 2018-04-01T00:00:00Z.
• 主题: article
• 在线阅读: Connect to this object online.

Current research on antiretroviral therapy is mainly focused in the development of new formulations or combinations of drugs belonging to already known targets. However, HIV-1 infection is not cured by current therapy and thus, new approaches are needed. Bevirimat was developed by chemical modificat...