Promiscuous, Multi-Target Lupane-Type Triterpenoids Inhibits Wild Type and Drug Resistant HIV-1 Replication Through the Interference With Several Targets

• Prif Awduron: Luis M. Bedoya (Awdur), Manuela Beltrán (Awdur), Javier García-Pérez (Awdur), Patricia Obregón-Calderón (Awdur), Oliver Callies (Awdur), Ignacio A. Jímenez (Awdur), Isabel L. Bazzocchi (Awdur), José Alcamí (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Frontiers Media S.A., 2018-04-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

Current research on antiretroviral therapy is mainly focused in the development of new formulations or combinations of drugs belonging to already known targets. However, HIV-1 infection is not cured by current therapy and thus, new approaches are needed. Bevirimat was developed by chemical modificat...