Comparative evaluation of biased agonists Sarcosine1, d‐Alanine8‐Angiotensin (Ang) II (SD Ang II) and Sarcosine1, Isoleucine8‐Ang II (SI Ang II) and their radioiodinated congeners binding to rat liver membrane AT1 receptors

• Main Authors: Natalia M. Noto (Author), Yazmin M. Restrepo (Author), Hong W. Pang (Author), Filipe Stoyell‐Conti (Author), Crystal A. West (Author), Robert C. Speth (Author)
• Format: Bog
• Udgivet: Wiley, 2023-02-01T00:00:00Z.
• Fag: article
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Abstract Angiotensin II analogue and β‐arrestin biased agonist TRV027 (Sarcosine1, d‐Alanine8‐Angiotensin (Ang) II; SD Ang II), developed by Trevena, Inc. in the early 2010s, brought hopes of a novel treatment for cardiovascular diseases, due to its ability to simultaneously cause signaling through...