A phase I, randomized study to evaluate the safety, tolerability, and pharmacokinetics of mefunidone in healthy subjects

• Main Authors: Mai Han (Author), Bishan Huo (Author), Gaoyun Hu (Author), Xin Zhang (Author), Gang Cui (Author), Wei Wu (Author), Na Mi (Author), Shixi Zhang (Author), Jiangli Jin (Author), Xing Lu (Author), Bidong Wu (Author), Chunyan Xiao (Author), Jing Wang (Author), Zheng Bian (Author), Jintong Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BackgroundMefunidone is a novel synthetic compound and is better when compared to pirfenidone for the anti-fibrotic treatment of renal fibrosis in end-stage renal disease. We conducted this first-in-human, phase I clinical trial to determine the safety, tolerability, and pharmacokinetic (PK) (includ...