Low-dose melittin is safe for intravitreal administration and ameliorates inflammation in an experimental model of uveitis

• Main Authors: Brenda Fernanda Moreira Castro (Author), Carolina Nunes da Silva (Author), Lídia Pereira Barbosa Cordeiro (Author), Sarah Pereira de Freitas Cenachi (Author), Daniel Vitor Vasconcelos-Santos (Author), Renes Resende Machado (Author), Luiz Guilherme Dias Heneine (Author), Luciana Maria Silva (Author), Armando Silva-Cunha (Author), Silvia Ligório Fialho (Author)
• Format: Bog
• Udgivet: Elsevier, 2022-01-01T00:00:00Z.
• Fag: article
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Uveitis is a group of sight-threatening ocular inflammatory disorders, whose mainstay of therapy is associated with severe adverse events, prompting the investigation of alternative treatments. The peptide melittin (MEL) is the major component of Apis mellifera bee venom and presents anti-inflammato...