Synthetic Circular RNA Functions as a miR-21 Sponge to Suppress Gastric Carcinoma Cell Proliferation

• Main Authors: Xi Liu (Author), John M. Abraham (Author), Yulan Cheng (Author), Zhixiong Wang (Author), Zhe Wang (Author), Guanjun Zhang (Author), Hassan Ashktorab (Author), Duane T. Smoot (Author), Robert N. Cole (Author), Tatiana N. Boronina (Author), Lauren R. DeVine (Author), C. Conover Talbot, Jr (Author), Zhengwen Liu (Author), Stephen J. Meltzer (Author)
• Format: Book
• Published: Elsevier, 2018-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

MicroRNA (miR) sponges containing miR binding sequences constitute a potentially powerful molecular therapeutic strategy. Recently, naturally occurring circular RNAs (circRNAs) were shown to function as efficient miR sponges in cancer cells. We hypothesized that synthetic circRNA sponges could achie...