Caffeine increases Nr1i3 expression and potentiates the effects of its ligand, TCPOBOP, in mice liver

• Main Authors: Heidge Fukumasu (Author), Arina Lázaro Rochetti (Author), Andreia Oliveira Latorre (Author), Pedro Ratto Lisboa Pires (Author), Tereza Cristina Silva (Author), Maria Lucia Zaidan Dagli (Author)
• Format: Book
• Published: Universidade de São Paulo, 2015-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Caffeine is one of the world's most consumed substances. It is present in coffee, green tea and guarana, among others. The xenobiotic-sensing nuclear receptor subfamily 1, group I, member 3 (Nr1i3), also known as the Constitutive Androstane Receptor (Car) is a key regulator of drug met...