A non-destructive NIR spectroscopic method combined with chemometry for simultaneous assay of paracetamol and caffeine in tablets

• Main Authors: Dana MUNTEAN (Author), Alina PORFIRE (Author), Cristian ALECU (Author), Sonia IURIAN (Author), Tibor CASIAN (Author), Alexandru GÂVAN (Author), Ioan TOMUTA (Author)
• Format: Book
• Published: Amaltea Medical Publishing House, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The use of near infrared (NIR) spectroscopy to predict the concentration of two active pharmaceutical ingredients (APIs), paracetamol and caffeine, in intact tablets, has been evaluated in this study. A partial least squares (PLS) regression model was developed using spectral data obtained on a cali...