Comparative Analysis of the Physicochemical and Biological Characteristics of Freeze-Dried PEGylated Cationic Solid Lipid Nanoparticles

• Main Authors: David A. Narváez-Narváez (Author), María Duarte-Ruiz (Author), Sandra Jiménez-Lozano (Author), Cristina Moreno-Castro (Author), Ronny Vargas (Author), Anna Nardi-Ricart (Author), Encarna García-Montoya (Author), Pilar Pérez-Lozano (Author), Josep Mª Suñé-Negre (Author), Cristina Hernández-Munain (Author), Carlos Suñé (Author), Marc Suñé-Pou (Author)
• Format: Book
• Published: MDPI AG, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cationic solid-lipid nanoparticles (cSLNs) have become a promising tool for gene and RNA therapies. PEGylation (PEG) is crucial in enhancing particle stability and protection. We evaluated the impact of PEG on the physicochemical and biological characteristics of cholesteryl-oleate cSLNs (CO-cSLNs)....