Spesolimab Efficacy and Safety in Patients with Moderate-to-Severe Palmoplantar Pustulosis: A Multicentre, Double-Blind, Randomised, Placebo-Controlled, Phase IIb, Dose-Finding Study

Spesolimab Efficacy and Safety in Patients with Moderate-to-Severe Palmoplantar Pustulosis: A Multicentre, Double-Blind, Randomised, Placebo-Controlled, Phase IIb, Dose-Finding Study

Abstract Introduction We evaluated the anti-interleukin-36 receptor antibody spesolimab in patients with moderate-to-severe palmoplantar pustulosis (PPP). Methods This phase IIb trial comprised a loading dose period to week (W) 4, then maintenance dosing to W52. Patients were randomised 2:1:1:1:2 to...

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Main Authors: A. David Burden (Author), Robert Bissonnette (Author), Alexander A. Navarini (Author), Masamoto Murakami (Author), Akimichi Morita (Author), Thomas Haeufel (Author), Binqi Ye (Author), Frank Baehner (Author), Tadashi Terui (Author)
Format: Book
Published: Adis, Springer Healthcare, 2023-09-01T00:00:00Z.
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