Clinically Relevant Concentrations of Polymyxin B and Meropenem Synergistically Kill Multidrug-Resistant <i>Pseudomonas aeruginosa</i> and Minimize Biofilm Formation

• Main Authors: Hasini Wickremasinghe (Author), Heidi H. Yu (Author), Mohammad A. K. Azad (Author), Jinxin Zhao (Author), Phillip J. Bergen (Author), Tony Velkov (Author), Qi Tony Zhou (Author), Yan Zhu (Author), Jian Li (Author)
• Format: Book
• Published: MDPI AG, 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The emergence of antibiotic resistance has severely impaired the treatment of chronic respiratory infections caused by multidrug-resistant (MDR) <i>Pseudomonas aeruginosa</i>. Since the reintroduction of polymyxins as a last-line therapy against MDR Gram-negative bacteria, resistance to...