Survival motor neuron protein regulates oxidative stress and inflammatory response in microglia of the spinal cord in spinal muscular atrophy

• Главные авторы: Shiori Ando (Автор), Daiki Osanai (Автор), Kei Takahashi (Автор), Shinsuke Nakamura (Автор), Masamitsu Shimazawa (Автор), Hideaki Hara (Автор)
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• Опубликовано: Elsevier, 2020-12-01T00:00:00Z.
• Предметы: article
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The deficiency of survival motor neuron (SMN) protein can result in the onset of spinal muscular atrophy (SMA), an autosomal recessive disorder characterized by a progressive loss of motor neurons and skeletal muscle atrophy. The mechanism underlying SMA pathology remains unclear. Here, we demonstra...