Identification of 2-(4-N,N-Dimethylaminophenyl)-5-methyl-1-phenethyl-1H-benzimidazole targeting HIV-1 CA capsid protein and inhibiting HIV-1 replication in cellulo

• Main Authors: Guzmán Alvarez (Author), Lisa van Pul (Author), Xavier Robert (Author), Zoraima Artía (Author), Ad C. van Nuenen (Author), Mathieu Long (Author), Natalia Sierra (Author), Williams Porcal (Author), Neeltje A. Kootstra (Author), Christophe Guillon (Author)
• Format: Book
• Published: BMC, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The capsid (CA) subunit of the HIV-1 Gag polyprotein is involved in several steps of the viral cycle, from the assembly of new viral particles to the protection of the viral genome until it enters into the nucleus of newly infected cells. As such, it represents an interesting therapeutic ta...