Design and Characterization of Inulin Conjugate for Improved Intracellular and Targeted Delivery of Pyrazinoic Acid to Monocytes

• Main Authors: Franklin Afinjuomo (Author), Thomas G. Barclay (Author), Ankit Parikh (Author), Yunmei Song (Author), Rosa Chung (Author), Lixin Wang (Author), Liang Liu (Author), John D. Hayball (Author), Nikolai Petrovsky (Author), Sanjay Garg (Author)
• Format: Book
• Published: MDPI AG, 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The propensity of monocytes to migrate into sites of mycobacterium tuberculosis (TB) infection and then become infected themselves makes them potential targets for delivery of drugs intracellularly to the tubercle bacilli reservoir. Conventional TB drugs are less effective because of poor intracellu...