The role of iron in anthracycline cardiotoxicity

• Main Authors: Elena eGammella (Author), Federica eMaccarinelli (Author), Paolo eBuratti (Author), Stefania eRecalcati (Author), Gaetano eCairo (Author)
• Format: Book
• Published: Frontiers Media S.A., 2014-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The clinical use of the antitumor anthracycline Doxorubicin is limited by the risk of severe cardiotoxicity. The mechanisms underlying anthracycline-dependent cardiotoxicity are multiple and remain uncompletely understood, but many observations indicate that interactions with cellular iron metabolis...