Anti-p53 autoantibody as early diagnostic and prognostic marker of bronchogenic carcinoma in smokers

• Main Authors: Mohammed B.M Sofyan (Author), Mohammad S.A Bakheet (Author), Mostafa M.M Alomairi (Author), Hamada Kawshtysayed (Author), Sameh Salahelden (Author)
• Format: Book
• Published: Wolters Kluwer Medknow Publications, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background Mutations in the tumor protein 53 (TP53) gene can lead to expression of mutant p53 proteins that accumulate in cancer cells and can induce circulating p53 antibodies in patients with cancer. Neoplastic transformation leads to elevated plasma sialic acid concentration through shedding or s...