Discovery of novel dual inhibitors of receptor tyrosine kinases EGFR and PDGFR-β related to anticancer drug resistance

• Main Authors: Tim Fischer (Author), Abdulkarim Najjar (Author), Frank Totzke (Author), Christoph Schächtele (Author), Wolfgang Sippl (Author), Christoph Ritter (Author), Andreas Hilgeroth (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

With ongoing resistance problems against the marketed EGFR inhibitors having a quinazoline core scaffold there is a need for the development of novel inhibitors having a modified scaffold and, thus, expected lower EGFR resistance problems. An additional problem concerning EGFR inhibitor resistance i...