Deep Tumor Penetration of Doxorubicin-Loaded Glycol Chitosan Nanoparticles Using High-Intensity Focused Ultrasound

• Main Authors: Yongwhan Choi (Author), Hyounkoo Han (Author), Sangmin Jeon (Author), Hong Yeol Yoon (Author), Hyuncheol Kim (Author), Ick Chan Kwon (Author), Kwangmeyung Kim (Author)
• Formato: Livro
• Publicado em: MDPI AG, 2020-10-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

The dense extracellular matrix (ECM) in heterogeneous tumor tissues can prevent the deep tumor penetration of drug-loaded nanoparticles, resulting in a limited therapeutic efficacy in cancer treatment. Herein, we suggest that the deep tumor penetration of doxorubicin (DOX)-loaded glycol chitosan nan...