Nobiletin, a Polymethoxy Flavonoid, Suppresses Bone Resorption by Inhibiting NFκB-Dependent Prostaglandin E Synthesis in Osteoblasts and Prevents Bone Loss Due to Estrogen Deficiency

Nobiletin, a polymethoxy flavonoid, prevents cancer and inflammation, but the roles of nobiletin in bone are unclear. We examined the effects of nobiletin on bone resorption in vitro and on bone mass in ovariectomized (OVX) mice in vivo. In vitro, nobiletin suppressed osteoclast formation and bone r...

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Main Authors: Suguru Harada (Author), Tsukasa Tominari (Author), Chiho Matsumoto (Author), Michiko Hirata (Author), Morichika Takita (Author), Masaki Inada (Author), Chisato Miyaura (Author)
Format: Book
Published: Elsevier, 2011-01-01T00:00:00Z.
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