Bivalent non-human gal-α1-3-gal glycan epitopes in the Fc region of a monoclonal antibody model can be recognized by anti-Gal-α1-3-Gal IgE antibodies
ABSTRACTMonoclonal antibody (mAb) production using non-human cells can introduce non-human glycan epitopes including terminal galactosyl-α1-3-galactose (α1-3-Gal) moieties. Cetuximab is a commercial mAb associated with causing anaphylaxis in some patients due to the binding of endogenous anti-α1-3-G...
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Main Authors: | Grayson Hatfield (Author), Lioudmila Tepliakova (Author), Jessica Tran (Author), Huixin Lu (Author), Michel Gilbert (Author), Roger Y. Tam (Author) |
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Format: | Book |
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Taylor & Francis Group,
2023-12-01T00:00:00Z.
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Online Access: | Connect to this object online. |
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