NSC746364, a G-Quadruplex-Stabilizing Agent, Suppresses Cell Growth of A549 Human Lung Cancer Cells Through Activation of the ATR/Chk1-Dependent Pathway

• Main Authors: Yun-Lung Chung (Author), Chun-Hsu Pan (Author), Wei-Hung Liou (Author), Ming-Jyh Sheu (Author), Wen-Hsin Lin (Author), Tsung-Chih Chen (Author), Hsu-Shan Huang (Author), Chieh-Hsi Wu (Author)
• Format: Book
• Published: Elsevier, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract.: The telomere is considered to be a potential target for cancer therapy. NSC746364, a novel G-quadruplex-stabilizing agent, has been found to have cytotoxic effects on various cancer cells. To date, its pharmacological mechanisms are still unknown. The goal of this study was to investigate...