Chiral Recognition R- and RS- of New Antifungal: Complexation/Solubilization/Dissolution Thermodynamics and Permeability Assay

• 主要な著者: Tatyana V. Volkova (著者), Olga R. Simonova (著者), Igor B. Levshin (著者), German L. Perlovich (著者)
• フォーマット: 図書
• 出版事項: MDPI AG, 2022-04-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Novel potential antifungal of 1,2,4-triazole class have been synthesized as pure enantiomer (R-98) and racemic (RS-186). The effect of 2-hydroxypropyl-β-cyclodextrin (<i>CD</i>) on the solubility and permeability of RS-186 and R-98 in terms of chiral recognition was investigated. Phase s...