ApoE isoform-dependent effects of xanthohumol on high fat diet-induced cognitive impairments and hippocampal metabolic pathways

• Main Authors: Payel Kundu (Author), Sarah Holden (Author), Ines L. Paraiso (Author), Reetesh Sudhakar (Author), Chloe McQuesten (Author), Jaewoo Choi (Author), Cristobal L. Miranda (Author), Claudia S. Maier (Author), Gerd Bobe (Author), Jan F. Stevens (Author), Jacob Raber (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Consumption of a high fat diet (HFD) is linked to metabolic syndrome and cognitive impairments. This is exacerbated in age-related cognitive decline (ACD) and in individuals with a genetic risk for Alzheimer's disease (AD). Apolipoprotein E (apoE) is involved in cholesterol metabolism. In human...