Cariporide Attenuates Doxorubicin-Induced Cardiotoxicity in Rats by Inhibiting Oxidative Stress, Inflammation and Apoptosis Partly Through Regulation of Akt/GSK-3β and Sirt1 Signaling Pathway

• Hoofdauteurs: Wenli Liao (Auteur), Zhiwei Rao (Auteur), Lingling Wu (Auteur), Yong Chen (Auteur), Cairong Li (Auteur)
• Formaat: Boek
• Gepubliceerd in: Frontiers Media S.A., 2022-06-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Background: Doxorubicin (DOX) is a potent chemotherapeutic agent with limited usage due to its cumulative cardiotoxicity. The Na+/H+ exchanger isoform 1 (NHE1) is a known regulator of oxidative stress, inflammation, and apoptosis. The present study was designed to investigate the possible protective...