Tiered approach to evaluate the CYP3A victim and perpetrator drug-drug interaction potential for vonoprazan using PBPK modeling and clinical data to inform labeling

Abstract Vonoprazan is metabolized extensively through CYP3A and is an in vitro time‐dependent inhibitor of CYP3A. A tiered approach was applied to understand the CYP3A victim and perpetrator drug-drug interaction (DDI) potential for vonoprazan. Mechanistic static modeling suggested vonoprazan is a...

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Main Authors: Darcy J. Mulford (Author), Diane Ramsden (Author), Liming Zhang (Author), Ingrid Michon (Author), Eckhard Leifke (Author), Neila Smith (Author), Hannah M. Jones (Author), Carmelo Scarpignato (Author)
Formato: Livro
Publicado em: Wiley, 2023-04-01T00:00:00Z.
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