Design of ultrahigh-affinity and dual-specificity peptide antagonists of MDM2 and MDMX for P53 activation and tumor suppression

• Main Authors: Xiang Li (Author), Neelakshi Gohain (Author), Si Chen (Author), Yinghua Li (Author), Xiaoyuan Zhao (Author), Bo Li (Author), William D. Tolbert (Author), Wangxiao He (Author), Marzena Pazgier (Author), Honggang Hu (Author), Wuyuan Lu (Author)
• Format: Book
• Published: Elsevier, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Peptide inhibition of the interactions of the tumor suppressor protein P53 with its negative regulators MDM2 and MDMX activates P53 in vitro and in vivo, representing a viable therapeutic strategy for cancer treatment. Using phage display techniques, we previously identified a potent peptide activat...