Skeletal muscle p53‐depletion uncovers a mechanism of fuel usage suppression that enables efficient energy conservation

• Main Authors: Georgia Lenihan‐Geels (Author), Francisco Garcia Carrizo (Author), Marina Leer (Author), Sabrina Gohlke (Author), Moritz Oster (Author), Sophie Pöhle‐Kronawitter (Author), Christiane Ott (Author), Alexandra Chadt (Author), Isabel N. Reinisch (Author), Markus Galhuber (Author), Chen Li (Author), Wenke Jonas (Author), Markus Jähnert (Author), Susanne Klaus (Author), Hadi Al‐Hasani (Author), Tilman Grune (Author), Annette Schürmann (Author), Tobias Madl (Author), Andreas Prokesch (Author), Michael Schupp (Author), Tim J. Schulz (Author)
• Format: Book
• Published: Wiley, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The ability of skeletal muscle to respond adequately to changes in nutrient availability, known as metabolic flexibility, is essential for the maintenance of metabolic health and loss of flexibility contributes to the development of diabetes and obesity. The tumour suppressor pro...