Synthesis, biological evaluation, and computational studies of N-benzyl pyridinium-curcumin derivatives as potent AChE inhibitors with antioxidant activity

• Главные авторы: Nafisah M. Al-Rifai (Автор), Nemeh M. Al-Khalileh (Автор), Jalal A. Zahra (Автор), Musa I. El-Barghouthi (Автор), Fouad H. Darras (Автор)
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• Опубликовано: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Предметы: article
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A library of N-benzylpyridinium-based compounds, 7a-j and 8a-j, was designed and synthesised as potential acetylcholinesterase) AChE (inhibitors. An in vitro assay for the synthesised compounds showed that most compounds had significant AChE inhibitory activities at the nanomolar and submicromolar l...