An Investigation of the Metabolism and Excretion of KD101 and Its Interindividual Differences: A Microtracing Mass Balance Study in Humans

• Main Authors: Anhye Kim (Author), Stephen R. Dueker (Author), Jun Gi Hwang (Author), Jangsoo Yoon (Author), Sang‐Won Lee (Author), Hye Suk Lee (Author), Byung‐Yong Yu (Author), Kyung‐Sang Yu (Author), Howard Lee (Author)
• Format: Book
• Published: Wiley, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The absorption, metabolism, and excretion (AME) profiles of KD101, currently under clinical development to treat obesity, were assessed in humans using accelerator mass spectrometry (AMS) after a single oral administration of KD101 at 400 mg and a microdose of 14C‐KD101 at ~ 35.2 μg with a total rad...