A Gain-of-Function Mutation in Nav1.6 in a Case of Trigeminal Neuralgia

• Main Authors: Brian S Tanaka (Author), Peng Zhao (Author), Fadia B Dib-Hajj (Author), Valerie Morisset (Author), Simon Tate (Author), Stephen G Waxman (Author), Sulayman D Dib-Hajj (Author)
• Format: Book
• Published: BMC, 2016-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Idiopathic trigeminal neuralgia (TN) is a debilitating pain disorder characterized by episodic unilateral facial pain along the territory of branches of the trigeminal nerve. Human pain disorders, but not TN, have been linked to gain-of-function mutations in peripheral voltage-gated sodium...