Application of Physiologically‐Based and Population Pharmacokinetic Modeling for Dose Finding and Confirmation During the Pediatric Development of Moxifloxacin

• Main Authors: Stefan Willmann (Author), Matthias Frei (Author), Gabriele Sutter (Author), Katrin Coboeken (Author), Thomas Wendl (Author), Thomas Eissing (Author), Jörg Lippert (Author), Heino Stass (Author)
• Format: Book
• Published: Wiley, 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Moxifloxacin is a widely used fluoroquinolone for the treatment of complicated intra‐abdominal infections. We applied physiologically‐based pharmacokinetic (PBPK) and population pharmacokinetic (popPK) modeling to support dose selection in pediatric patients. We scaled an existing adult PBPK model t...