Application of Physiologically‐Based and Population Pharmacokinetic Modeling for Dose Finding and Confirmation During the Pediatric Development of Moxifloxacin

• Những tác giả chính: Stefan Willmann (Tác giả), Matthias Frei (Tác giả), Gabriele Sutter (Tác giả), Katrin Coboeken (Tác giả), Thomas Wendl (Tác giả), Thomas Eissing (Tác giả), Jörg Lippert (Tác giả), Heino Stass (Tác giả)
• Định dạng: Sách
• Được phát hành: Wiley, 2019-09-01T00:00:00Z.
• Những chủ đề: article
• Truy cập trực tuyến: Connect to this object online.

Moxifloxacin is a widely used fluoroquinolone for the treatment of complicated intra‐abdominal infections. We applied physiologically‐based pharmacokinetic (PBPK) and population pharmacokinetic (popPK) modeling to support dose selection in pediatric patients. We scaled an existing adult PBPK model t...