Data‐driven personalization of a physiologically based pharmacokinetic model for caffeine: A systematic assessment

• Main Authors: Rebekka Fendt (Author), Ute Hofmann (Author), Annika R. P. Schneider (Author), Elke Schaeffeler (Author), Rolf Burghaus (Author), Ali Yilmaz (Author), Lars Mathias Blank (Author), Reinhold Kerb (Author), Jörg Lippert (Author), Jan‐Frederik Schlender (Author), Matthias Schwab (Author), Lars Kuepfer (Author)
• Format: Book
• Published: Wiley, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Physiologically based pharmacokinetic (PBPK) models have been proposed as a tool for more accurate individual pharmacokinetic (PK) predictions and model‐informed precision dosing, but their application in clinical practice is still rare. This study systematically assesses the benefit of usi...