Teleological role of L-2-hydroxyglutarate dehydrogenase in the kidney

• Main Authors: Garrett Brinkley (Author), Hyeyoung Nam (Author), Eunhee Shim (Author), Richard Kirkman (Author), Anirban Kundu (Author), Suman Karki (Author), Yasaman Heidarian (Author), Jason M. Tennessen (Author), Juan Liu (Author), Jason W. Locasale (Author), Tao Guo (Author), Shi Wei (Author), Jennifer Gordetsky (Author), Teresa L. Johnson-Pais (Author), Devin Absher (Author), Dinesh Rakheja (Author), Anil K. Challa (Author), Sunil Sudarshan (Author)
• Format: Book
• Published: The Company of Biologists, 2020-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

L-2-hydroxyglutarate (L-2HG) is an oncometabolite found elevated in renal tumors. However, this molecule might have physiological roles that extend beyond its association with cancer, as L-2HG levels are elevated in response to hypoxia and during Drosophila larval development. L-2HG is known to be m...