Bromo-Cyclobutenaminones as New Covalent UDP-<i>N</i>-Acetylglucosamine Enolpyruvyl Transferase (MurA) Inhibitors

Bromo-Cyclobutenaminones as New Covalent UDP-<i>N</i>-Acetylglucosamine Enolpyruvyl Transferase (MurA) Inhibitors

Drug discovery programs against the antibacterial target UDP-<i>N</i>-acetylglucosamine enolpyruvyl transferase (MurA) have already resulted in covalent inhibitors having small three- and five-membered heterocyclic rings. In the current study, the reactivity of four-membered rings was ca...

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Main Authors: David J. Hamilton (Author), Péter Ábrányi-Balogh (Author), Aaron Keeley (Author), László Petri (Author), Martina Hrast (Author), Tímea Imre (Author), Maikel Wijtmans (Author), Stanislav Gobec (Author), Iwan J. P. de Esch (Author), György Miklós Keserű (Author)
Format: Book
Published: MDPI AG, 2020-11-01T00:00:00Z.
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3rd Floor Main Library

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