VEGFA-targeting miR-agshRNAs combine efficacy with specificity and safety for retinal gene therapy

Retinal gene therapy using RNA interference (RNAi) to silence targeted genes requires both efficacy and safety. Short hairpin RNAs (shRNAs) are useful for RNAi, but high expression levels and activity from the co-delivered passenger strand may cause undesirable cellular responses. Ago2-dependent shR...

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主要な著者: Sidsel Alsing (著者), Thomas Koed Doktor (著者), Anne Louise Askou (著者), Emilie Grarup Jensen (著者), Ulvi Ahmadov (著者), Lasse Sommer Kristensen (著者), Brage Storstein Andresen (著者), Lars Aagaard (著者), Thomas J. Corydon (著者)
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出版事項: Elsevier, 2022-06-01T00:00:00Z.
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