A Compartmentalized Reduction in Membrane-Proximal Calmodulin Reduces the Immune Surveillance Capabilities of CD8+ T Cells in Head and Neck Cancer

• Main Authors: Ameet A. Chimote (Author), Vaibhavkumar S. Gawali (Author), Hannah S. Newton (Author), Trisha M. Wise-Draper (Author), Laura Conforti (Author)
• פורמט: ספר
• יצא לאור: Frontiers Media S.A., 2020-02-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

The limited ability of cytotoxic CD8+ T cells to infiltrate solid tumors and function within the tumor microenvironment presents a major roadblock to effective immunotherapy. Ion channels and Ca2+-dependent signaling events control the activity of T cells and are implicated in the failure of immune...