A Compartmentalized Reduction in Membrane-Proximal Calmodulin Reduces the Immune Surveillance Capabilities of CD8+ T Cells in Head and Neck Cancer
The limited ability of cytotoxic CD8+ T cells to infiltrate solid tumors and function within the tumor microenvironment presents a major roadblock to effective immunotherapy. Ion channels and Ca2+-dependent signaling events control the activity of T cells and are implicated in the failure of immune...
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| Main Authors: | , , , , |
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| Format: | Book |
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Frontiers Media S.A.,
2020-02-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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