Intracellular and Extracellular Lipopolysaccharide Signaling in Sepsis: Avenues for Novel Therapeutic Strategies

• Main Authors: Ramy S. Gabarin (Author), Manshu Li (Author), Paige A. Zimmel (Author), John C. Marshall (Author), Yimin Li (Author), Haibo Zhang (Author)
• Format: Book
• Published: Karger Publishers, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sepsis is defined as organ dysfunction due to a dysregulated systemic host response to infection. During gram-negative bacterial infection and other acute illness such as absorption from the gut infection, lipopolysaccharide (LPS) is a major mediator in sepsis. LPS is able to trigger inflammation th...