Evaluation of pharmacokinetics underlies the collaborated usage of lamivudine and oxymatrine in beagle dogs

• Main Authors: Zhenbao Li (Author), Lei Shang (Author), Chang Liu (Author), Panqin Ma (Author), Chunnuan Wu (Author), Wenjuan Zhang (Author), Yinghua Sun (Author), Yongjun Wang (Author), Xiaohong Liu (Author), Jin Sun (Author)
• Format: Book
• Published: Elsevier, 2016-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Combinational therapy of lamivudine and oxymatrine has been employed in the battle against hepatitis B virus in clinical setting. However, the pharmacokinetic behavior of the drug or active metabolism in intravenous/oral co-administration regime is poorly investigated. Herein, we evaluated the pharm...