A novel validated UPLC method for quantitation of lopinavir and ritonavir in bulk drug and pharmaceutical formulation with its impurities

• Main Authors: Gnana Deepika Killi (Author), Rama Krishna Maddinapudi (Author), Sathis Kumar Dinakaran (Author), Avasarala Harani (Author)
• Format: Bog
• Udgivet: Universidade de São Paulo, 2014-04-01T00:00:00Z.
• Fag: article
• Online adgang: Connect to this object online.

A simple gradient Ultra Performance liquid chromatographic method (UPLC) was developed for determination of lopinavir and ritonavir from its related impurities and assay for the first time. This method involves the use of a C18 (Acquity UPLC BEH C18, 50 × 2.1 mm, 1.7 µm) column thermostated at 30 oC...