JTT-130, a novel intestine-specific inhibitor of microsomal triglyceride transfer protein, ameliorates lipid metabolism and attenuates atherosclerosis in hyperlipidemic animal models

• Main Authors: Yasuko Mera (Author), Takashi Kawai (Author), Naoto Ogawa (Author), Naoya Odani (Author), Tomohiko Sasase (Author), Katsuhiro Miyajima (Author), Takeshi Ohta (Author), Makoto Kakutani (Author)
• Format: Book
• Published: Elsevier, 2015-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

JTT-130 was developed as an intestine-specific MTP inhibitor designed to rapidly catabolize after absorption to avoid causing hepatotoxicity due to hepatic MTP inhibition. In previous reports, we have demonstrated that JTT-130 suppresses dietary lipid absorption in the small intestine without induci...