Development of tooth regenerative medicine strategies by controlling the number of teeth using targeted molecular therapy

• Main Authors: Katsu Takahashi (Author), Honoka Kiso (Author), Akiko Murashima-Suginami (Author), Yoshihito Tokita (Author), Manabu Sugai (Author), Yasuhiko Tabata (Author), Kazuhisa Bessho (Author)
• Format: Book
• Published: BMC, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Analysis of various genetically modified mice, with supernumerary teeth, has revealed the following two intrinsic molecular mechanisms that increase the number of teeth. One plausible explanation for supernumerary tooth formation is the rescue of tooth rudiments. Topical application of cand...