Advancing cancer therapy: new frontiers in targeting DNA damage response

• Main Authors: Jiekun Qian (Author), Guoliang Liao (Author), Maohui Chen (Author), Ren-Wang Peng (Author), Xin Yan (Author), Jianting Du (Author), Renjie Huang (Author), Maojie Pan (Author), Yuxing Lin (Author), Xian Gong (Author), Guobing Xu (Author), Bin Zheng (Author), Chun Chen (Author), Zhang Yang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Genomic instability is a core characteristic of cancer, often stemming from defects in DNA damage response (DDR) or increased replication stress. DDR defects can lead to significant genetic alterations, including changes in gene copy numbers, gene rearrangements, and mutations, which accumulate over...