Advancing cancer therapy: new frontiers in targeting DNA damage response
Genomic instability is a core characteristic of cancer, often stemming from defects in DNA damage response (DDR) or increased replication stress. DDR defects can lead to significant genetic alterations, including changes in gene copy numbers, gene rearrangements, and mutations, which accumulate over...
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Frontiers Media S.A.,
2024-09-01T00:00:00Z.
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