Tritium labeling of antisense oligonucleotides via different conjugation agents

Abstract A novel approach to tritium-labeled antisense oligonucleotides (ASO) was established by conjugating N-succinimidyl propionate, as well as maleimide-derivatives, to the 3'-end of ASOs targeting metastasis-associated lung adenocarcinoma transcript 1 (Malat1) containing amino- or sulfhydr...

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Bibliographic Details
Main Authors: Martin R. Edelmann (Author), Christophe Husser (Author), Martina B. Duschmalé (Author), Guy Fischer (Author), Claudia Senn (Author), Erich Koller (Author), Andreas Brink (Author)
Format: Book
Published: SpringerOpen, 2021-11-01T00:00:00Z.
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