Tritium labeling of antisense oligonucleotides via different conjugation agents

• Asıl Yazarlar: Martin R. Edelmann (Yazar), Christophe Husser (Yazar), Martina B. Duschmalé (Yazar), Guy Fischer (Yazar), Claudia Senn (Yazar), Erich Koller (Yazar), Andreas Brink (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: SpringerOpen, 2021-11-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Abstract A novel approach to tritium-labeled antisense oligonucleotides (ASO) was established by conjugating N-succinimidyl propionate, as well as maleimide-derivatives, to the 3'-end of ASOs targeting metastasis-associated lung adenocarcinoma transcript 1 (Malat1) containing amino- or sulfhydr...