Fermentable carbohydrate stimulates FFAR2-dependent colonic PYY cell expansion to increase satiety

• Main Authors: Lucy Brooks (Author), Alexander Viardot (Author), Anastasia Tsakmaki (Author), Emilie Stolarczyk (Author), Jane K. Howard (Author), Patrice D. Cani (Author), Amandine Everard (Author), Michelle L. Sleeth (Author), Arianna Psichas (Author), Jelena Anastasovskaj (Author), Jimmy D. Bell (Author), Kim Bell-Anderson (Author), Charles R. Mackay (Author), Mohammad A. Ghatei (Author), Stephen R. Bloom (Author), Gary Frost (Author), Gavin A. Bewick (Author)
• Format: Book
• Published: Elsevier, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Dietary supplementation with fermentable carbohydrate protects against body weight gain. Fermentation by the resident gut microbiota produces short-chain fatty acids, which act at free fatty acid receptor 2 (FFAR2). Our aim was to test the hypothesis that FFAR2 is important in regulating...