Therapeutic administration of recombinant Paracoccin confers protection against paracoccidioides brasiliensis infection: involvement of TLRs.

• Main Authors: Ana Claudia Paiva Alegre-Maller (Author), Flávia Costa Mendonça (Author), Thiago Aparecido da Silva (Author), Aline Ferreira Oliveira (Author), Mateus Silveira Freitas (Author), Ebert Seixas Hanna (Author), Igor C Almeida (Author), Nicholas J Gay (Author), Maria Cristina Roque-Barreira (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Paracoccin (PCN) is an N-acetylglucosamine-binding lectin from the human pathogenic fungus Paracoccidioides brasiliensis. Recombinant PCN (rPCN) induces a T helper (Th) 1 immune response when prophylactically administered to BALB/c mice, protecting them against subsequent challenge with P. brasilien...