Therapeutic administration of recombinant Paracoccin confers protection against paracoccidioides brasiliensis infection: involvement of TLRs.

• Autores principales: Ana Claudia Paiva Alegre-Maller (Autor), Flávia Costa Mendonça (Autor), Thiago Aparecido da Silva (Autor), Aline Ferreira Oliveira (Autor), Mateus Silveira Freitas (Autor), Ebert Seixas Hanna (Autor), Igor C Almeida (Autor), Nicholas J Gay (Autor), Maria Cristina Roque-Barreira (Autor)
• Formato: Libro
• Publicado: Public Library of Science (PLoS), 2014-12-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Paracoccin (PCN) is an N-acetylglucosamine-binding lectin from the human pathogenic fungus Paracoccidioides brasiliensis. Recombinant PCN (rPCN) induces a T helper (Th) 1 immune response when prophylactically administered to BALB/c mice, protecting them against subsequent challenge with P. brasilien...