<i>Acanthaster planci</i> Inhibits PCSK9 Gene Expression via Peroxisome Proliferator Response Element (PPRE) and Activation of MEK and PKC Signaling Pathways in Human Liver Cells

• Main Authors: Nurjannatul Naim Kamaruddin (Author), Lukman Hakim Mohd Din (Author), Allicia Jack (Author), Aina Farahiyah Abdul Manan (Author), Habsah Mohamad (Author), Tengku Sifzizul Tengku Muhammad (Author)
• Format: Book
• Published: MDPI AG, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A constantly elevated level of low-density lipoprotein cholesterol (LDL-C) is mainly associated with the development of atherosclerosis. The use of statins as a treatment for reducing plasma LDL-C levels has led, in some cases, to adverse side effects, including a decrease in hepatic LDL receptor (L...