Design, synthesis and evaluation of 2, 6, 8-substituted Imidazopyridine derivatives as potent PI3Kα inhibitors

• Main Authors: Rui Chen (Author), Zhongyuan Wang (Author), Lijie Sima (Author), Hu Cheng (Author), Bilan Luo (Author), Jianta Wang (Author), Bing Guo (Author), Shunyi Mao (Author), Zhixu Zhou (Author), Jingang Peng (Author), Lei Tang (Author), Xinfu Liu (Author), Weike Liao (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Inhibition of PI3K pathway has become a desirable strategy for cancer treatment. In this work, a series of 2, 6, 8-substituted Imidazo[1,2-a]pyridine derivatives were designed and screened for their activities against PI3Kα and a panel of PI3Kα-addicted cancer cells. Among them, compound 35 was iden...