Oral Vaccination with Attenuated Salmonella typhimurium-Delivered TsPmy DNA Vaccine Elicits Protective Immunity against Trichinella spiralis in BALB/c Mice.

• Main Authors: Lei Wang (Author), Xiaohuan Wang (Author), Kuo Bi (Author), Ximeng Sun (Author), Jing Yang (Author), Yuan Gu (Author), Jingjing Huang (Author), Bin Zhan (Author), Xinping Zhu (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2016-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:Our previous studies showed that Trichinella spiralis paramyosin (TsPmy) is an immunomodulatory protein that inhibits complement C1q and C8/C9 to evade host complement attack. Vaccination with recombinant TsPmy protein induced protective immunity against T. spiralis larval challenge. Due...