In situ triggering antitumor efficacy of alcohol-abuse drug disulfiram through Cu-based metal-organic framework nanoparticles

• Main Authors: Lin Hou (Author), Yanlong Liu (Author), Wei Liu (Author), Mervat Balash (Author), Hongling Zhang (Author), Yi Zhang (Author), Huijuan Zhang (Author), Zhenzhong Zhang (Author)
• Format: Book
• Published: Elsevier, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Although approved as an alcohol-abuse drug, disulfiram (DSF) exhibited potential anticancer activity when chelated with copper (Cu). However, the low level of intrinsic Cu, toxicity originated from exogenous Cu supplementation, and poor stability of DSF in vivo severely limited its application in ca...