Design and synthesis of benzothiazole-based SLC-0111 analogues as new inhibitors for the cancer-associated carbonic anhydrase isoforms IX and XII

• Main Authors: Tarfah Al-Warhi (Author), Mostafa M. Elbadawi (Author), Alessandro Bonardi (Author), Alessio Nocentini (Author), Ahmed A. Al-Karmalawy (Author), Nada Aljaeed (Author), Ohoud J. Alotaibi (Author), Hatem A. Abdel-Aziz (Author), Claudiu T. Supuran (Author), Wagdy M. Eldehna (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this work, different series of benzothiazole-based sulphonamides 8a-c, 10, 12, 16a-b and carboxylic acids 14a-c were developed as novel SLC-0111 analogues with the goal of generating potent carbonic anhydrase (CA) inhibitors. The adopted strategy involved replacing the 4-fluorophenyl tail in SLC-...